BiochemistrySciencePeer-reviewed
An adaptor for feedback regulation of heme biosynthesis by the mitochondrial protease CLPXP
Thomas Cottle, Lydia Joh, Cori Posner…·Julia R. Kardon
The paper identifies POLDIP2 as a heme-sensing adaptor that facilitates CLPXP-mediated degradation of ALAS, elucidating the mechanism of heme-induced feedback regulation in heme biosynthesis.
10 citationstop 1%