Author

Adam DeCosta

Brandeis UniversityORCID 0000-0003-2652-8367Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 1 Organism:yeast· 1

Frequent Co-Authors

Julia R. KardoniD· 2 shared Cori PosneriD· 1 shared Dean R. CampagnaiD· 1 shared Lydia JohiD· 1 shared Mark D. FlemingiD· 1 shared Rebecca BarrickiD· 1 shared Sarah DucampiD· 1 shared Thomas CottleiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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2 shared papersBiochemistry

Julia R. KardonORCID

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2 papers

Recent·Most cited

An adaptor for feedback regulation of heme biosynthesis by the mitochondrial protease CLPXP

Thomas Cottle, Lydia Joh, Cori Posner, Adam DeCosta, Dean R. Campagna, Mark D. Fleming, Sarah Ducamp, Julia R. Kardon

The paper identifies POLDIP2 as a heme-sensing adaptor that facilitates CLPXP-mediated degradation of ALAS, elucidating the mechanism of heme-induced feedback regulation in heme biosynthesis.

Science · Jul 30, 2026Peer-reviewedBiochemistry

A mitochondrial insertion directs substrate selection and engagement by ClpX

Adam DeCosta, Rebecca Barrick, Julia R. Kardon

This paper identifies a mitochondrial insertion in ClpX that facilitates substrate recruitment and processing, with distinct roles in yeast and human systems.

bioRxiv · Feb 23, 2026 · PreprintBiochemistry