Author

Jonathan A. Cooper

Fred Hutch Cancer CenterORCID 0000-0002-8626-7827Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

David A. BakeriD· 2 shared Hannele Ruohola‐BakeriD· 2 shared Saurav KumariD· 2 shared Xinru WangiD· 2 shared Yan Ting ZhaoiD· 2 shared Adam NguyeniD· 1 shared Analisa Murray· 1 shared Anindya RoyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

David A. BakerORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 2, 2026

Integrin-independent Tie2 activation using de novo designed proteins

Clara McCurdy, Yan Ting Zhao, Saurav Kumar…·Hannele Ruohola‐Baker

This paper designs a de novo Tie2 binder that activates the Angiopoietin-Tie2 pathway without integrin engagement, showing improved therapeutic potential in a mouse model of ARDS.

DOI 10.64898/2026.05.01.718274

mousedeep learning

𝕏 PostBluesky

BioengineeringAdvanced MaterialsPeer-reviewedJun 9, 2025

De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine

Xinru Wang, Jordi Guillem‐Marti, Saurav Kumar…·David A. Baker

The paper designs de novo proteins called NeoNectins that specifically bind integrin α5β1, enhancing cell attachment and tissue integration in biomaterials.

9 citationstop 3%

protein structureexperimental assay

𝕏 PostBluesky