Author

Clara McCurdy

University of WashingtonORCID 0009-0008-8120-9776Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:drug response / drug discovery· 3 Research Focus:cell type annotation· 1 Approach:diffusion model· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

Brian CoventryiD· 2 shared David A. BakeriD· 2 shared Hannele Ruohola‐BakeriD· 2 shared Inna GoreshnikiD· 2 shared Andrew P. HinckiD· 1 shared Anne PinkiD· 1 shared Aude G. ChapuisiD· 1 shared Buwei HuangiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersBiochemistry

Brian CoventryORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 2, 2026

Integrin-independent Tie2 activation using de novo designed proteins

Clara McCurdy, Yan Ting Zhao, Saurav Kumar…·Hannele Ruohola‐Baker

This paper designs a de novo Tie2 binder that activates the Angiopoietin-Tie2 pathway without integrin engagement, showing improved therapeutic potential in a mouse model of ARDS.

DOI 10.64898/2026.05.01.718274

mousedeep learning

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BiochemistryNature CommunicationsPeer-reviewedJan 10, 2026

✦ In-depth digest

Improved protein binder design using -pairing targeted RFdiffusion

Isaac Sappington, Martin Toul, David S. Lee…·David A. Baker

Conditioning RFdiffusion on edge beta-strand pairing yields specific binders to polar targets, with in silico success above 9.2% versus 0.98% for hotspot-only conditioning.

33 citationstop 1%

protein structurestructural biology

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ImmunologybioRxivPreprintSep 18, 2024

Overcoming immune evasion from post-translational modification of a mutant KRAS epitope to achieve TCR-T cell-mediated antitumor activity

Jihoon William Lee, Emily Y. Chen, Taylor Hu…·Philip D. Greenberg

Tumor cell methylation of KRASG12V epitope in HLA-A2 permits immune evasion, and new TCRs were generated to overcome this with engineered cell therapy.

DOI 10.1101/2024.09.18.612965

humanproteomics

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