James W. Dear

Non-invasive quantification of hepatic necrosis from circulating alanine aminotransferase kinetics in acetaminophen-treated mice in vivo

This study uses serial ALT kinetics to estimate hepatic necrosis in vivo in acetaminophen-treated mice, showing better prediction accuracy than traditional methods and reducing animal use.

SLAMseq reveals transfer of RNA from liver to kidney in the mouse

The paper uses SLAMseq to detect RNA transfer from liver to kidney in mice, finding increased transfer after liver injury.

Extracellular RNA moves from the glomerulus to the renal tubule

The paper tracks extracellular RNA transfer from glomerular podocytes to renal tubular epithelial cells in vivo using a modified nucleobase and SLAMseq.