Amy H. Buck

The paper identifies exWAGO as an ancestral regulator of LTR retrotransposons, showing it binds sRNAs from TEs and non-autonomous LTRs in extracellular forms.

This study identifies an extracellular Argonaute protein from a parasitic nematode that can be internalized by mouse cells and shows it can be targeted for vaccine development.

This study uses 2-D organoids to show that parasitic nematodes and their secreted products affect host gene expression differently depending on their location at the intestinal epithelium.

This study identifies SID-2 as an extracellular vesicle protein in parasitic nematodes that does not function in environmental RNAi, suggesting a shift in its ancestral role.

The paper uses SLAMseq to detect RNA transfer from liver to kidney in mice, finding increased transfer after liver injury.

The paper identifies RNA-RNA interactions between RSV and miR-26/miR-27, showing their roles in cell cycle and antiviral immunity through target gene networks and nuclear localization.

The paper tracks extracellular RNA transfer from glomerular podocytes to renal tubular epithelial cells in vivo using a modified nucleobase and SLAMseq.

The paper develops methods to disentangle sRNA-Seq data from interacting species, validating them on nematode-mouse interactions.

The paper identifies an Argonaute protein secreted by a nematode that mediates the release of specific siRNAs into the host environment.