Chemical Genetic Targeting of the LRRK2 GTPase Domain
Rachel Prorok, Lawrence Zhu, Vickie Bowcut, Harry Xiaoying Wu, Keelan Z. Guiley, Johannes Morstein, Kevan M. Shokat
This study explores targeting the LRRK2 GTPase domain as an alternative to kinase inhibitors to reduce kinase activity with less toxicity.
bioRxiv · Sep 7, 2026 · PreprintMolecular Biology