Author

Keelan Z. Guiley

University of California, Santa CruzORCID 0000-0002-8149-4262Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein structure prediction· 3 Organism:human· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1

Frequent Co-Authors

Sarvind Mani TripathiiD· 2 shared Seth M. RubiniD· 2 shared Tilini U. WijeratneiD· 2 shared Alexander Hirschi· 1 shared Ali BashiriD· 1 shared Anushweta AsthanaiD· 1 shared Arthur Jeremy WillseyiD· 1 shared Belinda WangiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMolecular Biology

Sarvind Mani TripathiORCID

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Author profile →

4 papers

Recent·Most cited

Chemical Genetic Targeting of the LRRK2 GTPase Domain

Rachel Prorok, Lawrence Zhu, Vickie Bowcut, Harry Xiaoying Wu, Keelan Z. Guiley, Johannes Morstein, Kevan M. Shokat

This study explores targeting the LRRK2 GTPase domain as an alternative to kinase inhibitors to reduce kinase activity with less toxicity.

bioRxiv · Sep 7, 2026 · PreprintMolecular Biology

A foundational atlas of autism protein interactions reveals molecular convergence

Belinda Wang, Rasika S. Vartak, Yefim Zaltsman, Zun Zar Chi Naing, Kelsey M. Hennick, Benjamin J. Polacco, Ali Bashir, Manon Eckhardt, Mehdi Bouhaddou, Jiewei Xu, Nawei Sun, Micaela C. Lasser, Yuan M. Zhou, Justin McKetney, Keelan Z. Guiley, , Nevan J. Krogan

The paper constructs a PPI network of 100 high-confidence ASD genes, identifies novel interactions, and uses AlphaFold-Multimer to prioritize variants for functional validation in organoids.

bioRxiv · Dec 3, 2023 · PreprintSystems Biology

The MuvB Complex Binds and Stabilizes Nucleosomes Downstream of the Transcription Start Site of Cell-Cycle Dependent Genes

Anushweta Asthana, Parameshwaran Ramanan, Alexander Hirschi, Keelan Z. Guiley, Tilini U. Wijeratne, Robert I. Shelansky, Michael J. Doody, Haritha Narasimhan, Hinrich Boeger, Sarvind Mani Tripathi, Gerd A. Müller, Seth M. Rubin

This study determines the structure of the MuvB complex and shows it binds and stabilizes nucleosomes downstream of the transcription start site to repress gene expression.

Nature Communications · Jan 26, 2022Peer-reviewedMolecular Biology

A Long Lost Key Opens an Ancient Lock: Drosophila Myb Causes a Synthetic Multivulval Phenotype in Nematodes

Paul J. Vorster, Paul D. Goetsch, Tilini U. Wijeratne, Keelan Z. Guiley, Laura Andrejka, Sarvind Mani Tripathi, Braden J Larson, Seth M. Rubin, Susan Strome, Joseph S. Lipsick

This paper shows that Drosophila Myb can bind to nematode LIN9 and LIN52 proteins and cause a synthetic multivulval phenotype in C. elegans, despite their distant evolutionary divergence.

Biology Open · Jan 1, 2020Peer-reviewedMolecular Biology