Kevan M. Shokat

This study explores targeting the LRRK2 GTPase domain as an alternative to kinase inhibitors to reduce kinase activity with less toxicity.

This paper elucidates the structural mechanisms by which LRRK2 is activated and autoinhibited, showing how mutations affect these processes and suggesting therapeutic strategies.

The paper identifies benzoxaboroles as selective binders of eIF4E, revealing stereoselective interactions and structural insights into their binding mechanism.

The paper demonstrates that Chai-1, a deep learning tool, can accurately predict covalent K-Ras(G12C) complexes using single sequences without multiple sequence alignments.

This paper shows that daraxonrasib, a pan-Ras TCI, acts as a GAP mimic and synergizes with K-Ras Switch-II inhibitors to enhance pathway suppression and reduce toxicity.

This paper identifies BisRoc, a dimeric rocaglate ligand that suppresses translation more potently and specifically than monomeric RocA by promoting multivalent eIF4A-RNA assembly.

This study uses GENEVA to analyze drug response variations in cancer cells, revealing mitochondrial activation's role in KRAS inhibition and EMT as a resistance mechanism.

This study uses CRISPR screens to identify PTGES3 as a novel modulator of AR protein levels and function in prostate cancer, showing its role in therapy resistance.

The paper identifies 7-deazapurine protein conjugation as essential for type IV CBASS immunity, revealing the roles of Cap9 and Cap10 in this process.

This paper develops RocASO, a molecular glue-oligonucleotide conjugate that selectively inhibits mRNA translation by targeting specific sequences, showing potent antiviral activity against SARS-CoV-2.

This paper shows IL-13 and IL-17A activate β1 integrins through an NF-κB/Rho kinase/PIP5K1γ pathway, enhancing force transmission in airway smooth muscle and linking this to asthma pathology.

The paper investigates acute rapamycin treatment in a maternal inflammation mouse model of autism, showing rapid rescue of behavioral and functional dysfunctions linked to mTOR pathway activation.

Cellpanelr identifies mutation and expression biomarkers from cell line panel response data using DepMap datasets.

A genome-wide CRISPR screen identifies CSDE1 as a key regulator of hepatic LDLR mRNA decay in vivo, making it a promising target for heart disease.

This study identifies mTOR-mediated translational activation as a key mechanism for rapid wound closure and regeneration in axolotls, distinct from non-regenerative mammals.

This study demonstrates that dual drug administration of RapaLink-1 and RapaBlock selectively inhibits mTORC1 in the brain while protecting it in the periphery, reducing side effects and moderating alcohol use in mice.