An immunobiliary single-cell atlas resolves crosstalk of type 2 cDCs and γδT cells in cholangitis
Stefan Thomann, Helene Hemmer, Ankit Agrawal, Sukanya Basu, Judith Schaf, Sagar, Fabian Imdahl, Tanja Poth, Marcell Tóth, Christina E. Zielinski, Tobias Poch, Jenny Krause, Andreas Rosenwald, Katja Breitkopf‐Heinlein, Nuh N. Rahbari, Dominic Grün
This study creates a single-cell atlas of the immunobiliary niche in cholangitis, revealing interactions between type 2 conventional dendritic cells and γδT cells that drive fibrosis.
bioRxiv · Jul 10, 2025 · PreprintImmunology