Tanja Poth

The paper identifies extracellular glutathione catabolism as a driver of metastasis by enabling proliferation and oxidative stress resistance in metabolically challenging microenvironments.

The paper introduces CHOCOLAT-G2P, a method integrating functional genomics and spatial transcriptomics to study genotype-phenotype relationships in tumors, revealing zonation patterns and epistasis in liver cancer.

This study creates a single-cell atlas of the immunobiliary niche in cholangitis, revealing interactions between type 2 conventional dendritic cells and γδT cells that drive fibrosis.

This study shows that systemic TREX1 inhibition enhances anti-tumor immunity by increasing T cell infiltration and activity in tumors while sparing other tissues.

This study maps the single-cell transcriptional and morphological changes in the mouse female reproductive tract across the estrus cycle, decidualization, and aging, revealing age-related fibrosis and inflammation.

This study shows that overexpressing human APOBEC3B in mice causes lethality through RNA editing and organ dysfunction.