Fabian Imdahl

Glycosylated GM-CSF expands B-1b cells and B-1b plasma cells and programs them for immunosuppression

This study shows glycosylated GM-CSF expands immunosuppressive B-1b plasma cells and promotes regulatory functions, while non-glycosylated GM-CSF drives pro-inflammatory responses.

Immunological liver-skin axis: a systemic Vγ4+ γδT17 cell responselinks psoriasis-like inflammation and MASLD

This study identifies Vγ4+ γδT17 cells as a link between psoriasis and MASLD, showing their role in systemic inflammation and hepatic remodeling, with clinical relevance of IL-17-targeted therapy.

Research advance: Unexpected plasticity in the life cycle of Trypanosoma brucei

This study shows slender Trypanosoma brucei can infect both teneral and non-teneral tsetse flies without supplements, and remains transcriptionally distinct from stumpy forms during differentiation.

An immunobiliary single-cell atlas resolves crosstalk of type 2 cDCs and γδT cells in cholangitis

This study creates a single-cell atlas of the immunobiliary niche in cholangitis, revealing interactions between type 2 conventional dendritic cells and γδT cells that drive fibrosis.

Adult dorsal root ganglion glial cells exhibit neurogenic potential upon reprogramming

This study shows adult mouse DRG glial cells can dedifferentiate into neural progenitor-like cells and express neuronal and glial markers, suggesting potential for sensory circuit regeneration.

Genetically perturbed myelin as a risk factor for neuroinflammation-driven axon degeneration

The paper shows that genetically perturbed myelin increases neuroinflammation-driven axon degeneration through immune-glial interactions in mice.