Sagar

Memory T Cells in MHC-Deficient Humanized Mice

This study compares T cell development in humanized mice with and without murine MHC, finding that busulfan conditioning in MHC-deficient mice promotes activated T cells while irradiation favors naive T cells.

GFI1 as a novel regulator of γδ T cell development and the IL-17/IFNγ lineage commitment

This paper identifies GFI1 as a regulator of γδ T cell development, showing it restricts IL-17-producing cells and promotes other γδ T cell subsets through repression of MAF.

Streptococcal meningoencephalitis dynamically shapes developmental monocyte and macrophage trajectories in the CNS

This study shows that streptococcal meningoencephalitis alters monocyte and macrophage dynamics in the dura by shifting their origin from skull bone marrow to peripheral sources and increasing MDP-Mo-derived cells.

Crosstalk between Stromal Cells and Macrophages Shapes Host Immunity to Mycobacteria

This study investigates how stromal cells and macrophages interact during mycobacterial infection, revealing their roles in shaping immune responses and granuloma formation.

M-CSF drives alveolar macrophage plasticity during development and cytomegalovirus infection

This study shows that M-CSF drives alveolar macrophage plasticity during development and CMV infection, increasing ISG expression and modulating infection susceptibility.

Postnatal Maturation of Dendritic Epidermal T Cells and Langerhans Cells Follows Distinct Differentiation Trajectories Independent of Microbiota

This study maps the postnatal differentiation trajectories of dendritic epidermal T cells and Langerhans cells in mice, showing they develop independently of each other and microbial colonization.

Mycobacterial infection uncovers plasticity of Kupffer cells

The paper investigates KC plasticity in mycobacterial infections, finding that KClow cells derived from bona fide KCs exhibit unique antimycobacterial activity and adaptability.

Colibactin-producing E. coli promote carcinogenesis of gastroesophageal adenocarcinoma and simultaneously induce autophagy and differentiation

This study shows colibactin-producing E. coli promote GEAC carcinogenesis by increasing proliferation, DNA damage, and cancer pathways, while also inducing autophagy and differentiation.

An immunobiliary single-cell atlas resolves crosstalk of type 2 cDCs and γδT cells in cholangitis

This study creates a single-cell atlas of the immunobiliary niche in cholangitis, revealing interactions between type 2 conventional dendritic cells and γδT cells that drive fibrosis.

Eomes restricts Brachyury functions at the onset of mammalian gastrulation

The paper investigates the distinct gene-regulatory functions of Eomes and Brachyury in mouse embryos and stem cells, showing Eomes restricts Brachyury activity to ensure proper lineage specification.

Spatiotemporal sequence of mesoderm and endoderm lineage segregation during mouse gastrulation

The paper investigates the spatiotemporal sequence of mesoderm and endoderm lineage segregation during mouse gastrulation using genetic fate labeling, imaging, and scRNA-seq.

Benchmarking Single-Cell RNA Sequencing Protocols for Cell Atlas Projects

This study benchmarks 13 scRNA-seq protocols to evaluate their effectiveness in characterizing cell types and states for cell atlas projects.

A Human Liver Cell Atlas: Revealing Cell Type Heterogeneity and Adult Liver Progenitors by Single-Cell RNA-sequencing

This paper constructs a human liver cell atlas using single-cell RNA-sequencing to identify new cell subtypes and progenitors, and applies it to study liver disease and engraftment.

Deciphering the Regulatory Landscape of γδ T Cell Development by Single-Cell RNA-Sequencing

This study uses single-cell RNA-sequencing to uncover the developmental trajectory of γδ T cells, identifying c-MAF as a key regulator of IL-17-producing γδ T cell differentiation.

The Polycomb-dependent epigenome controls β-cell dysfunction, dedifferentiation and diabetes

This study identifies chromatin-state signatures linked to β-cell dysfunction and diabetes by combining epigenome mapping with single-cell transcriptomics in mice and humans.

FateID infers cell fate bias in multipotent progenitors from single-cell RNA-seq data

FateID quantifies cell fate bias in multipotent progenitors using single-cell RNA-seq data, revealing a common progenitor population for B cells and plasmacytoid dendritic cells.