Author

William C. Forrester

ORCID 0000-0002-8640-8204Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Ajamete KaykasiD· 1 shared Benika J. PinchiD· 1 shared Carsten Russ· 1 shared Chaoyang YeiD· 1 shared Claudio R. ThomaiD· 1 shared Daniel J. Ho· 1 shared Dennis L. BuckleyiD· 1 shared Dustin DovalaiD· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Ajamete KaykasORCID

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2 papers

Recent·Most cited

Molecular BiologyCell chemical biologyPeer-reviewedSep 8, 2021

A Strategy to Assess the Cellular Activity of E3 Ligases against Neo-Substrates using Electrophilic Probes

Benika J. Pinch, Dennis L. Buckley, Scott Gleim…·Claudio R. Thoma

This paper introduces a method to assess E3 ligase activity against neo-substrates using electrophilic probes, demonstrating its effectiveness with VHL and SPSB2.

20 citations

experimental assay

Molecular BiologyNature MedicinePeer-reviewedJun 8, 2018

P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells

Robert J. Ihry, Kathleen A. Worringer, Max R. Salick…·Ajamete Kaykas

This study shows that CRISPR/Cas9 induces toxicity in human pluripotent stem cells, which is dependent on TP53 and hinders genome engineering.

978 citationstop 1%

humanCRISPR screen