Max R. Salick

A Pooled Cell Painting CRISPR Screening Platform Enables de novo Inference of Gene Function by Self-supervised Deep Learning

This paper introduces a pooled CRISPR screening platform combined with self-supervised deep learning to infer gene function from morphological phenotypes without target-specific biomarkers.

CellSIUS provides sensitive and specific detection of rare cell populations from complex single cell RNA-seq data

The paper benchmarks scRNA-seq methods and introduces CellSIUS, a tool that improves detection of rare cell populations and identifies their functional signatures in human stem cell differentiation.

Genome-wide screens in accelerated human stem cell-derived neural progenitor cells identify Zika virus host factors and drivers of proliferation

P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells

This study shows that CRISPR/Cas9 induces toxicity in human pluripotent stem cells, which is dependent on TP53 and hinders genome engineering.