Robert J. Ihry

The paper uses patient brain organoids to show that 16p11.2 CNVs affect RBFOX1 expression and link it to neurodevelopmental disorders.

DRUG-seq provides high-throughput, unbiased transcriptomic data for drug discovery, demonstrating reproducibility and mechanism-of-action resolution for diverse compounds.

TRAWLING simplifies aberrant splicing detection by providing a splicing-aware transcriptome reference, improving RNAseq analysis across multiple datasets.

This study shows that CRISPR/Cas9 induces toxicity in human pluripotent stem cells, which is dependent on TP53 and hinders genome engineering.