Channelrhodopsin Ion Selectivity Determines Mechanisms and Efficacy of Optogenetic Defibrillation in Human Atria and Ventricles
Sophia Ohnemus, Albert Dasí, Ahmed F. Ramadan…·Franziska Schneider‐Warme
This study compares the defibrillation efficacy of different channelrhodopsins in human cardiac tissue using simulations, finding that ion selectivity affects arrhythmia termination mechanisms and success.