Alfonso Bueno‐Orovio

Molecular and Structural Basis of Cardiac Remodelling in Niemann-Pick Type C

This study identifies cardiac involvement in Niemann-Pick type C through ECG abnormalities, fibrosis, and transcriptomic changes in patients and Npc1-/- mice.

MonoAlg3D: Enabling Cardiac Electrophysiology Digital Twins with an Efficient Open Source Scalable Solver on GPU Clusters

This paper introduces a GPU-based cardiac electrophysiology solver that enables fast and scalable simulations, demonstrating significant speedup and integration into a digital twin pipeline.

T-World: A highly general computational model of a human ventricular myocyte

T-World is a computational model of human ventricular myocytes that accurately replicates physiological processes and identifies arrhythmia risks, with applications in drug response prediction.

Towards prospective in-silico trials in atrial fibrillation: the case of polypharmacological SK and K2P channel block

The paper uses in-silico trials to evaluate the efficacy of SK and K2P channel block in atrial fibrillation, finding that combined block significantly improves cardioversion success.