Author

Stefaan C. De Smedt

Ghent UniversityORCID 0000-0002-8653-2598Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

Kevin BraeckmansiD· 4 shared Deep PunjiD· 3 shared Félix SauvageiD· 3 shared Katrien RemautiD· 3 shared Bernd VanmeerhaegheiD· 2 shared Chloë De ClercqiD· 2 shared Weiran LiiD· 2 shared Yera Ye. UssembayeviD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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4 shared papersBiophysics

Kevin BraeckmansORCID

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Author profile →

4 papers

Recent·Most cited

Converting Lysosomes into Photothermal Organelles Enables Nanoparticle-Free Tumor Ablation via Intracellular Vapor Bubbles

Tao Lu, Cristina Muntean, Félix Sauvage, Deep Punj, Herlinde De Keersmaecker, Femke Baeke, Riet Maria De Rycke, Kelly Lemeire, Philippe Tummers, Weiran Li, Chloë De Clercq, Bernd Vanmeerhaeghe, Kaat Durinck, Olivier De Wever, Katrien Remaut, , Koen Raemdonck

This paper demonstrates nanoparticle-free tumor ablation using lysosomal entrapment of dyes to generate vapor bubbles under laser light.

Science Advances · Sep 25, 2026Peer-reviewedBioengineering

Photodisruption of the inner limiting membrane promotes retinal engraftment of stem-cell derived retinal ganglion cells

Emma De Coster, Kaat De Clerck, Chloë De Clercq, Weiran Li, Deep Punj, Bernd Vanmeerhaeghe, Jonie Verdonck, Stefaan C. De Smedt, Kevin Braeckmans, Hanieh Hadady, Katrien Remaut, Thomas V. Johnson, Karen Peynshaert

This study shows that photodisrupting the inner limiting membrane improves the engraftment of stem-cell derived retinal ganglion cells in retinal explants.

Investigative Ophthalmology & Visual Science · Feb 26, 2026Peer-reviewedPharmacology & Toxicology

Lipid-stabilized ICG nanoaggregates for the photodisruption of vitreous opacities

Pouria Ramezani, Jan Félix, Yera Ye. Ussembayev, Mariana Hugo Silva, Ine Lentacker, Rein Verbeke, Kevin Braeckmans, Stefaan C. De Smedt, Félix Sauvage

This paper develops lipid-stabilized ICG nanoaggregates that enhance photodisruption of vitreous opacities while reducing retinal toxicity compared to free ICG.

Materials Today Bio · Jan 16, 2026Peer-reviewedBiophysics

Photothermal transport for guiding nanoparticles through the vitreous humor

Léa Guerassimoff, Yera Ye. Ussembayev, Louise De Clerck, Deep Punj, Martijn van den Broek, Filip Beunis, Katrien Remaut, Kevin Braeckmans, Stefaan C. De Smedt, Félix Sauvage

This study demonstrates photothermal transport of nanoparticles through the vitreous humor using pulsed-lasers and indocyanine green, enabling guided drug delivery to the retina.

Advanced Science · Dec 22, 2025Peer-reviewedBiophysics