Author
Ghent UniversityORCID 0000-0002-8436-9467Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Pouria Ramezani, Jan Félix, Yera Ye. Ussembayev…·Félix Sauvage
This paper develops lipid-stabilized ICG nanoaggregates that enhance photodisruption of vitreous opacities while reducing retinal toxicity compared to free ICG.
Julie Andries, Martin Toul, Jan Félix…·Savvas N. Savvides
This study reveals the structural mechanisms of IL-36R activation by IL-36γ and IL-37 and spesolimab's allosteric antagonism, providing a blueprint for therapeutic targeting.
Danielle M. Clancy, Alba Sanz-Sanjuan, Elisabeth Gilis…·Savvas N. Savvides
This study determines the cryo-EM structure of the Themis-Grb2 complex, revealing its role as a dynamic structural hub in T cell receptor signaling and its functional importance in T cell development.
Jan Félix, Steven De Munck, J. Fernando Bazán, Savvas N. Savvides
The paper reanalyzes cryo-EM data to reveal a 2:1 stoichiometry of ALK-ALKAL2 complexes, resolving discrepancies with previous structural studies.
Yehudi Bloch, Jan Félix, Romain Merceron…·Savvas N. Savvides
The paper reports cryo-EM structures of fully assembled IL-12/IL-23 receptor complexes, revealing structural insights and differences in their interactions with receptors.
Alexandra Tsirigotaki, Ann Dansercoer, Koen H. G. Verschueren…·Kenneth Verstraete
This study reveals the structure and mechanism of Leptin-mediated LEP-R assembly, showing a 3:3 stoichiometry and highlighting the role of Leptin restructuring in activating signaling.