Wnt/β-catenin is required for proprioception by coordinating the multi-compartment development of muscle spindles
Qingyuan Guo, Ava Gatterer, Avital Rosner, Sharon Krief, Fabian S. Passini, Ron Rotkopf, Noa Wigoda, Michael Tsoory, Bavat Bornstein, Elazar Zelzer
This study shows that the Wnt/β-catenin pathway is essential for proprioception by coordinating the development of muscle spindle components through both cell-autonomous and non-cell-autonomous mechanisms.
bioRxiv · Dec 18, 2024 · PreprintDevelopmental Biology