The paper estimates heritability for height and BMI using whole-genome sequence data and finds that rare variants contribute significantly to the missing heritability.

Nature Genetics · Mar 1, 2022Peer-reviewedGenetics

Expanding the pool of public controls for GWAS via a method for combining genotypes from arrays and sequencing

Ravi Mathur, Fang Fang, Nathan Gaddis, Dana B. Hancock, Michael H. Cho, John E. Hokanson, Laura Jean Bierut, Sharon Marie Lutz, Kendra A. Young, Albert V. Smith, Edwin K. Silverman, Grier P. Page, Eric Otto Johnson

This paper introduces a method to combine genotypes from genotyping arrays and whole genome sequencing to expand public controls for GWAS, improving power for non-European ancestries.

bioRxiv · Oct 19, 2021 · PreprintBioinformatics

Expanding the Genetic Architecture of Nicotine Dependence and its Shared Genetics with Multiple Traits: Findings from the Nicotine Dependence GenOmics (iNDiGO) Consortium

Bryan C. Quach, Michael A. Bray, Nathan Gaddis, Mengzhen Liu, Teemu Palviainen, Camelia C. Minică, Stephanie M. Zellers, Richard Sherva, Fazil Alıev, Michael Nothnagel, Kendra A. Young, Jesse A. Marks, Hannah E. Young, Megan Ulmer Carnes, Yuelong Guo, , Dana B. Hancock

The paper identifies novel genetic loci associated with nicotine dependence and shows genetic correlations with other smoking traits and comorbidities using genome-wide association studies.

Nature Communications · Nov 3, 2020Peer-reviewedGenomics