Laura Jean Bierut

A Polygenic Score for Smoking Persistence Captures Differences in Cessation Age

This paper develops a polygenic score for smoking persistence and finds it is associated with earlier or later cessation ages across diverse populations.

Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.

This study performs a multi-ancestral GWAS of DSM-defined nicotine dependence, finding genetic correlations with other substance use disorders and health traits, and identifying a strong general addiction liability factor.

Genomic Insights for Personalized Care: Motivating At-Risk Individuals Toward Evidence-Based Health Practices

The paper develops polygenic risk scores to stratify lung cancer and smoking cessation risk, showing significant odds ratios in diverse populations and planning clinical trials to evaluate interventions.

Predicting alcohol-related memory problems in older adults: A machine learning study with multi-domain features

This study uses machine learning to predict alcohol-related memory problems in older adults by integrating multi-domain features including brain connectivity, polygenic risk, and lifestyle factors.

Evaluation of methods incorporating biological function and GWAS summary statistics to accelerate discovery

This study evaluates 18 functional weighting methods to enhance GWAS discovery, finding some methods can nominate high PPV variants for multiple traits without increasing sample size.

Expanding the pool of public controls for GWAS via a method for combining genotypes from arrays and sequencing

This paper introduces a method to combine genotypes from genotyping arrays and whole genome sequencing to expand public controls for GWAS, improving power for non-European ancestries.

Multi-omics integration analysis identifies novel genes for alcoholism with potential link to neurodegenerative diseases

The paper integrates GWAS data with multi-omics datasets to identify novel genes for alcohol use disorder and link them to neurodegenerative diseases.

Expanding the Genetic Architecture of Nicotine Dependence and its Shared Genetics with Multiple Traits: Findings from the Nicotine Dependence GenOmics (iNDiGO) Consortium

The paper identifies novel genetic loci associated with nicotine dependence and shows genetic correlations with other smoking traits and comorbidities using genome-wide association studies.

Genome-wide DNA methylation differences in nucleus accumbens of smokers vs. nonsmokers

This study identifies DNA methylation differences in the nucleus accumbens of smokers versus nonsmokers, revealing both shared and tissue-specific CpGs associated with smoking.

Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium

The paper compares genome-wide data from opioid use and dependence cases to identify genetic associations and differences between exposure and dependence.

Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior

The paper analyzes rare coding variants in smoking and drinking behavior using exome chip data, finding that they contribute to phenotypic variation but require larger samples for individual variant associations.

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

This study conducts the largest GWAS for PTSD, identifying 6 genome-wide significant loci in European and African ancestries and highlighting novel biological pathways.

Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome

This study identifies gene expression changes in the prenatal human cortex due to maternal smoking and links them to neuropsychiatric disorder risk genes.

Childhood socioeconomic status moderates genetic predisposition for peak smoking

The paper examines how childhood socioeconomic status interacts with genetic risk to influence peak cigarette consumption in adulthood.

Genome-wide analysis of risk-taking behaviour and cross-disorder genetic correlations in 116,255 individuals from the UK Biobank cohort

This study identifies genetic loci associated with risk-taking behavior and finds shared genetic risk with several psychiatric and physical disorders using UK Biobank data.

Association Between Substance Use Disorder And Polygenic Liability To Schizophrenia

The paper investigates the genetic link between schizophrenia and substance use disorder, finding shared polygenic liability across multiple datasets.