The role of matrix metalloproteinase-9 (MMP-9) in neurodevelopmental deficits and experience-dependent structural plasticity in Xenopus laevis tadpoles
Sayali V. Gore, Eric J. James, Lin-Chien Huang, Jenn J. Park, Andrea P. Berghella, Adrian C. Thompson, Hollis T. Cline, Carlos D. Aizenman
This study shows that elevated MMP-9 activity during early neurodevelopment causes neural circuit hyperconnectivity and behavioral deficits in Xenopus tadpoles, which can be reversed by blocking MMP-9.
eLife · Jul 20, 2021Peer-reviewedNeuroscience