Hollis T. Cline

Atypical tetracyclines promote longevity and ferroptotic neuroprotection via translation attenuation

This paper identifies atypical tetracyclines that promote longevity and neuroprotection by inhibiting cytosolic translation, independent of classical mechanisms and antibiotic activity.

Microglia-to-neuron signaling increases lipid droplet metabolism, enhancing neuronal network activity

The paper investigates how microglia-to-neuron signaling via APOE4 affects neuronal network activity and lipid droplet metabolism during inflammation.

Activity-dependent synthesis of Emerin gates neuronal plasticity by regulating proteostasis

The paper identifies Emerin as an activity-induced protein that gates neuronal plasticity by inhibiting protein synthesis and altering dendritic spine morphology.

Adeno-Associated Viral Tools to Trace Neural Development and Connectivity Across Amphibians

This paper identifies AAV serotypes effective for transducing amphibian CNS cells and develops tools for neural circuit tracing and manipulation in multiple amphibian species.

X-Tracker: Automated Analysis of Xenopus Tadpole Visual Avoidance Behavior

X-Tracker automates the analysis of Xenopus tadpole visual avoidance behavior, accurately detecting and scoring encounters without manual intervention.

Visual neurons recognize complex image transformations

The paper shows that tectal neurons encode complex visual transformations through temporally dynamic responses and experience-dependent tuning.

Postsynaptic receptors regulate presynaptic neurotransmitter stability through trans-synaptic bridges

The paper shows that postsynaptic receptors influence presynaptic transmitter stability via trans-synaptic bridges, ensuring synaptic fidelity.

Phosphorylation of pyruvate dehydrogenase marks the inhibition of in vivo neuronal activity

The paper identifies phosphorylated pyruvate dehydrogenase (pPDH) as an in vivo marker for neuronal inhibition, correlating with reduced action potential firing and detectable across various inhibitory conditions.

BRCA1 and ELK-1 regulate Neural Progenitor Cell Fate in the Optic Tectum in response toVisual Experience in Xenopus laevis tadpoles

The paper identifies BRCA1 and ELK-1 as regulators of visual experience-dependent neural progenitor cell fate in Xenopus laevis optic tectum using transcriptomic and in vivo imaging analyses.

BigNeuron: A resource to benchmark and predict best-performing algorithms for automated reconstruction of neuronal morphology

BigNeuron benchmarks automatic neuron reconstruction algorithms using gold standard annotations and image quality metrics, showing that consensus methods outperform individual algorithms.

Neuronal membrane proteasomes homeostatically regulate neural circuit activity in vivo and are required for learning-induced behavioral plasticity

This study shows neuronal membrane proteasomes regulate neural activity and are essential for learning-induced behavioral plasticity in Xenopus laevis tadpoles.

The role of matrix metalloproteinase-9 (MMP-9) in neurodevelopmental deficits and experience-dependent structural plasticity in Xenopus laevis tadpoles

This study shows that elevated MMP-9 activity during early neurodevelopment causes neural circuit hyperconnectivity and behavioral deficits in Xenopus tadpoles, which can be reversed by blocking MMP-9.

Cell-autonomous regulation of structural and functional plasticity in inhibitory neurons by excitatory synaptic inputs

The paper shows that reducing excitatory synaptic inputs in inhibitory neurons decreases inhibitory synapses and disrupts plasticity and behavior.

Role of the Visual Experience-Dependent Nascent Proteome in Neuronal Plasticity

The paper identifies novel proteins synthesized in response to visual experience in Xenopus tectal neurons and shows their role in structural and behavioral plasticity.

Exosomes regulate Neurogenesis and Circuit Assembly in a Model of Rett Syndrome

This study shows that exosomes from control neural cultures can rescue neural development defects in Rett Syndrome by influencing neuron number, apoptosis, and synaptic function.