Eran R. Andrechek

Tumor-derived FXII engages the intrinsic coagulation cascade to support breast cancer liver metastasis.

This study identifies tumor-derived FXII as a driver of liver metastasis in breast cancer by engaging the intrinsic coagulation cascade, with anti-coagulation reducing metastasis in a mouse model.

Neuronal innervation of breast cancer promotes metastatic dissemination

This study investigates the role of neuronal innervation in breast cancer metastasis using a MMTV-PyMT model and denervation with RTX, finding that denervation reduces metastasis without affecting tumor growth.

Mammary Alveolar Proliferation and Differentiation During Early Pregnancy is Regulated by E2F5

This study shows E2F5 promotes differentiation of luminal progenitors into alveolar precursors during early pregnancy, coordinating proliferation and differentiation in mammary development.

Unraveling the role of receptor-like protein tyrosine phosphatase PTPRH in cell signaling regulation and biological processes of non-small cell lung cancer

This study identifies PTPRH's role in NSCLC by revealing its interactions and signaling effects, showing it suppresses tumor growth and migration.

Evaluating cell lines as models for metastatic cancer through integrative analysis of open genomic data

This study evaluates the genomic similarity between breast cancer cell lines and metastatic samples, finding significant differences and highlighting organoids as better models.

Integrated sequence and gene expression analysis of mouse models of breast cancer reveals critical events with human parallels

The paper analyzes genomic and transcriptomic data from mouse breast cancer models to identify genomic events with parallels in human cancers and their functional impacts.