Carsten Knutsen

The paper shows that YAP-dependent inflammatory signaling in adult mouse lung endothelium contributes to ALI, absent in weanling mice, suggesting age-dependent differences in ARDS pathogenesis.

This study shows that postnatal VEGFR2 abrogation blocks Cap2 differentiation by preventing the transition from Cap1 to CapINT, impairing alveolarization and activating fibroblasts.

The paper creates a transcriptional map of endothelial cell zonation in the pulmonary vascular tree using scRNA-seq and identifies vessel size and arterio-venous polarity gradients.

The paper uses single-cell transcriptomics and in-situ imaging to study lung mesenchymal cell diversity during development and hyperoxia, finding delayed diversity and emergence of Acta1+ cells under hyperoxic conditions.

The paper profiles the transcriptional development and injury sensitivity of lung endothelial subtypes during postnatal growth, revealing distinct transcriptomic changes and differential responses to hyperoxia.