Author

Steven Barnes

University of California, Los AngelesORCID 0000-0003-0496-1645Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Alfredo Arrigo SaduniD· 1 shared Anastassia N. AlexandrovaiD· 1 shared Daniel GuioniD· 1 shared Igor MandriciD· 1 shared James C. R. GroveiD· 1 shared Kevin NguyeniD· 1 shared Matteo A. PellegriniiD· 1 shared Pujan AjmeraiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Alfredo Arrigo SadunORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintApr 23, 2026

Molecular Basis of Mitochondrial Complex I Disruption by m.14484T>C-Induced Leber Hereditary Optic Neuropathy

Pujan Ajmera, Daniel Guion, Steven Barnes…·Anastassia N. Alexandrova

This study identifies how the m.14484T>C mutation in ND6 subunit of complex I disrupts quinone binding and proton pumping, leading to LHON through altered hydrogen bond networks and redox chemistry.

1 citation

humanbiophysical modeling

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Developmental BiologybioRxivPreprintOct 27, 2020

Single cell transcriptomic analyses reveal the impact of bHLH factors ATOH7 and Neurog2 on human retinal organoid development

Xiangmei Zhang, Igor Mandric, Kevin Nguyen…·Xian-Jie Yang

This study uses single-cell transcriptomics to show that ATOH7 and Neurog2 regulate human retinal progenitor states and neuroblast fate by modulating bHLH factor expression.

DOI 10.1101/2020.10.27.358135

humanscRNA-seq

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