A distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia
Nikolay S. Markov, Ziyou Ren, Karolina J. Senkow, Rogan A. Grant, Catherine A. Gao, Elizabeth S. Malsin, Lango Sichizya, Hermon G. Kihshen, Kathryn A. Helmin, Milica Jovisic, Jason M Arnold, Xóchitl G. Pérez-Leonor, Hiam Abdala‐Valencia, Suchitra Swaminathan, Julu Nwaezeapu, , Karen M. Ridge
The paper examines alveolar T cell responses in SARS-CoV-2 pneumonia patients, finding that early interferon signaling and targeting of structural proteins correlate with better clinical outcomes.
Nature Immunology · Aug 13, 2024Peer-reviewedSystems Biology