Standardisation of cell-free DNA measurements: An International Study on Comparability of Low Concentration DNA Measurements using cancer variants
Daniel G. Burke, Alison S. Devonshire, Leonardo B. Pinheiro, Gerwyn M. Jones, Kate R. Griffiths, Ana Fernández-González, Michael Forbes-Smith, Jacob L. H. McLaughlin, Kerry R. Emslie, Christopher Weidner, Joachim Mankertz, John Emerson Leguizamón, Marcelo Neves de Medeiros, Roberto Becht Flatschart, Antônio Marcos Saraiva, , Jim F. Huggett
This study evaluates the comparability of cell-free DNA measurements using digital PCR across 12 laboratories, showing high technical accuracy for variant copy number and allele frequency.
bioRxiv · Sep 6, 2023 · PreprintGenetics