Nanopore-based cell-free DNA fragmentation and methylation profiles from the cerebral spinal fluid of patients with lung cancer brain metastases
Tianqi Chen, Xiangqi Bai, Georgiana Burnside, Thy Trang Hoang Trinh, Melanie Hayden Gephart, Billy T. Lau, Hanlee P. Ji
This study analyzes DNA fragmentation and methylation in CSF-derived cfDNA from NSCLC-BMET patients and finds distinct patterns compared to controls and plasma-derived cfDNA.
bioRxiv · Jul 28, 2025 · PreprintGenomics