Author

Bhairavi Srinageshwar

Harvard UniversityORCID 0000-0002-8763-545XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Andrew JiangiD· 1 shared Brigitte Demelo· 1 shared David H. BeieriD· 1 shared Diane E. LucenteiD· 1 shared Esaria OliveriD· 1 shared Eunhye LeeiD· 1 shared Faaiza Saif· 1 shared Ihn Sik SeongiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperGenetics

Andrew JiangORCID

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1 paper

Recent·Most cited

Huntington's disease LIG1 modifier variant increases ligase fidelity and suppresses somatic CAG repeat expansion

Eunhye Lee, Wonju Kim, David H. Beier, Yejin Lee, Marina V. Kovalenko, Faaiza Saif, Esaria Oliver, Bhairavi Srinageshwar, Ryan Murtha, Marissa A Andrew, Andrew Jiang, Tammy Gillis, Brigitte Demelo, Jayla Ruliera, Diane E. Lucente, , Ihn Sik Seong

This paper investigates the protective effect of the LIG1 K845N variant in Huntington's disease by showing it increases ligase fidelity and suppresses somatic CAG repeat expansion.

Proceedings of the National Academy of Sciences · Mar 2, 2026Peer-reviewedGenetics