Author

Marissa A Andrew

Massachusetts General Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Organism:human· 2 Approach:statistical model· 1

Frequent Co-Authors

Marina V. KovalenkoiD· 4 shared Ricardo Mouro PintoiD· 4 shared Vanessa Chantal WheeleriD· 4 shared C. Frank BennettiD· 2 shared Cassandra A. McHughiD· 2 shared David HowlandiD· 2 shared Deanna M. MarchioniniiD· 2 shared Hilary A. WilkinsoniD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetics

Marina V. KovalenkoORCID

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4 papers

Recent·Most cited

Huntington's disease LIG1 modifier variant increases ligase fidelity and suppresses somatic CAG repeat expansion

Eunhye Lee, Wonju Kim, David H. Beier, Yejin Lee, Marina V. Kovalenko, Faaiza Saif, Esaria Oliver, Bhairavi Srinageshwar, Ryan Murtha, Marissa A Andrew, Andrew Jiang, Tammy Gillis, Brigitte Demelo, Jayla Ruliera, Diane E. Lucente, , Ihn Sik Seong

This paper investigates the protective effect of the LIG1 K845N variant in Huntington's disease by showing it increases ligase fidelity and suppresses somatic CAG repeat expansion.

Proceedings of the National Academy of Sciences · Mar 2, 2026Peer-reviewedGenetics

Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding

Ella W. Mathews, Sydney R. Coffey, Annette Gärtner, Jillian Belgrad, Robert M. Bragg, Daniel O’Reilly, Jeffrey P. Cantle, Cassandra A. McHugh, Ashley Summers, Joachim Fentz, Tom Schwagarus, Antje Cornelius, Ioannis Lingos, Zoe N. Burch, Marina V. Kovalenko, , Jeffrey B. Carroll

This study investigates how different HTT-lowering therapies affect somatic instability in HD mice, finding that transcriptional repression and CAG repeat binding reduce SI without lowering HTT levels.

Nature Communications · Nov 14, 2025Peer-reviewedNeuroscience

Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via MLH3 splice redirection to suppress expansion

Jennie C. L. Roy, Antonia G. Vitalo, Marissa A Andrew, Eduarda Mota‐Silva, Marina V. Kovalenko, Zoe N. Burch, Anh M. Nhu, Paula E. Cohen, Ed Grabczyk, Vanessa Chantal Wheeler, Ricardo Mouro Pinto

This study shows that targeting the MLH3 endonuclease domain reduces somatic CAG expansion in Huntington's disease models and patient cells.

Nucleic Acids Research · Feb 23, 2021Peer-reviewedGenetics

Huntingtin lowering reduces somatic instability at CAG-expanded loci

Sydney R. Coffey, Marissa A Andrew, Heather Ging, Joseph Hamilton, Michael D. Flower, Marina V. Kovalenko, Robert M. Bragg, Jeffrey P. Cantle, Cassandra A. McHugh, José M. Carrillo, Julie-Anne Rodier, Deanna M. Marchionini, Hilary A. Wilkinson, Seung Kwak, David Howland, , Jeffrey B. Carroll

This study shows that reducing huntingtin protein levels decreases somatic instability in CAG-expanded loci in both mouse models and human neurons.

bioRxiv · Jul 23, 2020 · PreprintNeuroscience