Li Fan

A Single-cell Spatiotemporal Atlas Encoding Age-dependent Evolution of the Ischemic Penumbra

This study creates a spatiotemporal transcriptomic atlas of the ischemic penumbra in young and aged mice, revealing age-dependent molecular changes and potential therapeutic targets.

Single-nucleus chromatin accessibility identifies a critical role for TWIST1 in idiopathic pulmonary fibrosis myofibroblast activity

The paper identifies TWIST1 as a critical regulator of myofibroblast activity in IPF using single-nucleus ATAC-seq and scRNA-seq integration.

Integrative Analysis of Spatial Transcriptome with Single-cell Transcriptome and Single-cell Epigenome in Mouse Lungs after Immunization

This study integrates spatial transcriptome, single-cell RNA-seq, and single-cell ATAC-seq data from mouse lungs after immunization to identify cell types and their spatial dynamics.