Eleanor Valenzi

HALO models temporal causal relations in single-cell multi-omics data by distinguishing coupled and decoupled latent representations, revealing lineage specification dynamics in AT2 cells.

The paper identifies transcription factor networks driving fibrotic lung disease using multiomic single-cell data from SSc-ILD and control lungs.

The paper identifies LEF1 isoforms as key regulators of cellular senescence and aging through transcriptomic analysis and validation in human and mouse models.

The paper identifies TWIST1 as a critical regulator of myofibroblast activity in IPF using single-nucleus ATAC-seq and scRNA-seq integration.

The paper identifies four novel genetic variants associated with IPF survival, including a PCSK6 variant, and suggests PCSK6 as a prognostic biomarker and therapeutic target.