Christoph Diehl

In vitro transcription-based biosensing of glycolate for prototyping of a complex enzyme cascade

This paper develops an in vitro transcription-based biosensing workflow to quantify glycolate production in the CETCH cycle, showing high correlation with LC-MS at lower cost and faster speed.

An interdependent Metabolic and Genetic Network shows emergent properties in vitro

This study constructs a metabolic and genetic linked in vitro network that generates its own building blocks from non-living matter and demonstrates life-like behavior.

A versatile active learning workflow for optimization of genetic and metabolic networks

The paper introduces METIS, an active learning workflow for optimizing genetic and metabolic networks, demonstrating significant improvements in efficiency with minimal experiments.