The paper applies Bayesian statistics to metabolomics data from human ME/CFS cohorts, revealing more consistent and biologically meaningful metabolic differences compared to frequentist methods.

Metabolites · Aug 31, 2023Peer-reviewedBioinformatics

Emergence of the East-Central-South-African genotype of Chikungunya virus in Brazil and the city of Rio de Janeiro may have occurred years before surveillance detection

Thiago Moreno L. Souza, Yasmine Rangel Vieira, Edson Oliveira Delatorre, Giselle Barbosa-Lima, Raul Leal Faria Luiz, Alexandre Gomes Vizzoni, Komal Jain, Milene Dias Miranda, Nishit Bhuva, Jan F. Gogarten, James Ng, Riddhi Thakkar, Andrea Surrage Calheiros, Ana Paula Teixeira Monteiro, Patrícia Torres Bozza, , Nischay Mishra

Scientific Reports · Feb 26, 2019Peer-reviewedGenomics

Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

F. Kyle Satterstrom, Jack A. Kosmicki, Jiebiao Wang, Michael S. Breen, Silvia De Rubeis, Joon‐Yong An, Minshi Peng, Ryan L. Collins, Jakob Grove, Lambertus Klei, Christine R. Stevens, Jennifer G. Reichert, Maureen Mulhern, Mykyta Artomov, Sherif Gerges, , Kaija Puura

This study identifies 99 genes associated with autism spectrum disorder through large-scale exome sequencing, showing differences in mutation frequencies between ASD and severe neurodevelopmental delay groups.

Cell · Jan 1, 2019Peer-reviewedGenetics