Oliver Fiehn

Multi-Tissue Metabolomic Signatures of Five Longevity Interventions Converge on Ergothioneine and Lipid Remodeling in Male UM-HET3 Mice

This study identifies shared metabolic changes across five longevity interventions in mice, highlighting ergothioneine and lipid remodeling as key features.

Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon states

The paper identifies coordinated variation between immune systems and microbiomes in healthy humans, linking it to tonic interferon states.

Discrimination of Normal from Slow-Aging Mice by Plasma Metabolomic and Proteomic Features

The paper uses machine learning to identify plasma metabolomic and proteomic features that distinguish slow-aging mice from controls, finding triglycerides with varying fatty acid chain lengths as key predictors.

Heat Shock-Induced PI(4)P Increase Drives HSPA1A Translocation to the Plasma Membrane in Cancer and Stressed Cells through PI4KIII Alpha Activation

Dysregulation of innate immunity and cellular metabolism through virus-induced deISGylation

This study shows that SARS-CoV-2 deISGylation by PLpro suppresses innate immunity and promotes viral replication by modulating cellular metabolism.

Heat-Induced Phosphatidylserine Changes Drive HSPA1A's Plasma Membrane Localization

This study shows heat-induced phosphatidylserine (PS) increases drive HSPA1A's plasma membrane localization, with PS synthesis inhibition reducing this localization.

Resolving multi-image spatial lipidomic responses to inhaled toxicants by machine learning

The paper uses machine learning to analyze spatial lipidomic changes in mouse lungs exposed to allergens and ozone, revealing sex-specific lipid distribution differences.

Dynamic Lipidome Reorganization in Response to Heat Shock Stress

This study investigates lipidomic and transcriptomic changes in HeLa cells under heat shock and recovery, revealing extensive lipid remodeling and transcriptional regulation.

Introducing identification probability for automated and transferable assessment of metabolite identification confidence in metabolomics and related studies

The paper proposes identification probability as an automated and transferable method to assess metabolite identification confidence in metabolomics.

Composition of saliva metabolome is significantly associated with SARS-CoV2 infection and with severity of COVID-19 disease

The study identifies saliva metabolite changes associated with SARS-CoV-2 infection and disease severity, highlighting potential non-invasive biomarkers for COVID-19.

APOE Genotype and Biological Age Impact Inter-Omic Associations Related to Bioenergetics

The paper identifies APOE genotype-related metabolite associations with biological age and bioenergetics in humans, showing counterintuitive patterns in {varepsilon}2 and {varepsilon}4 carriers.

Structural annotation of full-scan MS data: A unified solution for LC-MS and MS imaging analyses

The paper introduces ms1-id, a tool for structural annotation of MS1 data in LC-MS and MS imaging, enabling level 2/3 annotation and uncovering previously overlooked metabolites.

The lipidome of posttraumatic stress disorder

This study analyzes the lipidome of PTSD patients and trauma-exposed non-PTSD individuals, finding sex-specific lipid subclass alterations linked to PTSD severity and health outcomes.

IDSL.GOA: Gene Ontology Analysis for Interpreting Metabolomic datasets

The paper introduces IDSL.GOA, a tool for Gene Ontology analysis of metabolomic datasets, highlighting its ability to identify overrepresented GO terms not covered by existing pathway databases.

HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver

This study shows that P2-HNF4 regulates ketogenesis in the liver and is involved in circadian metabolism, with implications for gender-specific ketone body levels.

Lipid metabolism drives allele-specific early-stage hypertrophic cardiomyopathy

This study identifies allele-specific metabolic differences in HCM mouse models, linking lipid metabolism to early-stage cardiac dysfunction.

Bayesian statistics improves biological interpretability of metabolomics data from human cohorts

The paper applies Bayesian statistics to metabolomics data from human ME/CFS cohorts, revealing more consistent and biologically meaningful metabolic differences compared to frequentist methods.

The unknown lipids project: harmonized methods improve compound identification and data reproducibility in an inter-laboratory untargeted lipidomics study

The paper improves compound identification and inter-laboratory reproducibility in untargeted lipidomics using harmonized methods and spectral analysis.

A Universal Language for Finding Mass Spectrometry Data Patterns

MassQL, an open-source query language, lets users search raw mass spectrometry data from any vendor for isotope, fragmentation and neutral-loss patterns, from one file to entire public repositories.

Mouse models of NADK2 deficiency analyzed for metabolic and gene expression changes to elucidate pathophysiology

This study analyzes NADK2 deficiency in mouse models to identify metabolic and gene expression changes, revealing similarities and differences with another neurological disease model.

Gut microbiome-linked metabolites in the pathobiology of depression and anxiety - a role for bile acids

This study identifies associations between bile acid profiles and symptoms of depression and anxiety in MDD patients, finding higher anxiety correlates and treatment failure predictors.

Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature

The paper links indoxyl sulfate, a gut microbiome-derived metabolite, to anxiety symptoms and specific brain connectivity patterns in patients with depression.

Alterations in Acylcarnitines, Amines, and Lipids Inform about Mechanism of Action of Citalopram/Escitalopram in Major Depression

The paper uses targeted metabolomics to analyze changes in acylcarnitines, amines, and lipids in response to citalopram/escitalopram treatment in MDD patients, identifying metabolic correlates of treatment response.

Hexosamine biosynthetic pathway integrates circadian and metabolic signals to regulate daily rhythms in protein O-linked N-acetylglucosaminylation

MS-DIAL 4: accelerating lipidomics using an MS/MS, CCS, and retention time atlas

MS-DIAL 4 provides a comprehensive lipidome atlas with retention time, collision cross section, and MS/MS data to standardize and accelerate lipidomics research.

Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics data and text mining

The paper identifies under-reported metabolic genes as potential drug targets in ERneg breast tumors using multi-omics data and text mining.

A comprehensive plasma metabolomics dataset for a cohort of mouse knockouts within the international mouse phenotyping consortium

The paper provides a metabolomics dataset from 30 mouse gene knockouts and wildtypes, identifying 832 metabolites across multiple analytical methods.

Serum triglycerides in Alzheimer’s disease: Relation to neuroimaging and CSF biomarkers

The paper investigates the association between triglyceride principal component scores and Alzheimer's disease biomarkers in the ADNI cohort, finding significant links with MCI, AD, and specific brain structures.

Sets of Co-regulated Serum Lipids are Associated with Alzheimer Disease Pathophysiology

The paper identifies lipid sets in blood associated with Alzheimer's disease biomarkers and clinical symptoms using lipidomic profiling in the ADNI1 cohort.