Leslie J. Baier

De novo genome assemblies from two Indigenous Americans from Arizona identify new polymorphisms in non-reference sequences

This study generates de novo genome assemblies from two Indigenous Americans, identifies non-reference sequences, and shows they improve variant detection in underrepresented populations.

The power of TOPMed imputation for the discovery of Latino enriched rare variants associated with type 2 diabetes

The paper demonstrates that TOPMed imputation improves the identification of rare variants associated with type 2 diabetes in Latino populations, leading to novel associations and better polygenic scores.

Characterization of exome variants and their metabolic impact in 6,716 American Indians from Southwest US

This study uses whole exome sequencing in 6,716 American Indians to identify metabolic trait-associated variants, finding unique pLOF and nonsynonymous variants linked to BMI, diabetes, and lipid levels.