Joseph E. Sanfilippo

Orthogonal microfluidic approaches reveal force-enhanced migration of bacterial populations on surfaces

This study shows that increased shear force enhances upstream migration of Pseudomonas aeruginosa by increasing twitching motility speed through changes in cell orientation.

Flow-driven delivery boosts antibiotic effectiveness by overwhelming bacterial defenses

This study shows flow enhances antibiotic effectiveness by overcoming bacterial defenses in Pseudomonas aeruginosa through microfluidic experiments and simulations.

Detoxification of host-relevant H2O2 shapes Pseudomonas aeruginosa population gradients in flow

This study shows how Pseudomonas aeruginosa uses local H2O2 detoxification to protect downstream cells in flow, creating spatial gradients.

Flow rapidly replenishes scarce nutrients to promote bacterial growth

This study shows that flow replenishes nutrients for bacterial growth at low concentrations, challenging traditional lab culture methods.

Flow-induced bending of flagella controls bacterial surface behavior

This study shows how shear force bends flagella to control surface behavior in Pseudomonas aeruginosa by altering flagellar positioning and rotation.

Combining multiple stressors unexpectedly blocks bacterial migration and growth

The paper shows that combining physical and chemical stressors significantly reduces bacterial growth and migration, contradicting previous studies that used single stressors.

Fluid flow overcomes antimicrobial resistance by boosting delivery

This study shows that fluid flow enhances antimicrobial delivery to overcome resistance in Pseudomonas aeruginosa by outcompeting bacterial neutralization mechanisms.