Matthias D. Koch

The paper quantifies the energetic cost of type IV pili (T4P) construction and operation across bacterial species, finding significant variation in energy investment.

The paper identifies how the Pil-Chp system regulates type IV pilus dynamics in Pseudomonas aeruginosa by modulating cAMP levels and affecting fiber length, count, and extension rate.

This study shows flow enhances antibiotic effectiveness by overcoming bacterial defenses in Pseudomonas aeruginosa through microfluidic experiments and simulations.

This study shows Pseudomonas aeruginosa uses energy-dependent T4P idling to balance dispersal and infection in fluctuating nutrient environments.

This study shows that pilus length in Pseudomonas aeruginosa determines virulence by revealing a hidden subpopulation of non-contributing filaments and shows extension dynamics, not retraction force, as the key constraint.

This study shows that flow replenishes nutrients for bacterial growth at low concentrations, challenging traditional lab culture methods.

The paper identifies a prophage protein that modulates pilus dynamics to prevent phage progeny destruction, enhancing survival through quorum sensing.

This study shows that fluid flow enhances antimicrobial delivery to overcome resistance in Pseudomonas aeruginosa by outcompeting bacterial neutralization mechanisms.