Computational design of a single-domain antibody that specifically recognizes WT1 peptide-loaded class I MHC
Tae-Sung Oh, Sung Gwe Ahn, Seonghyuk Suh, Joo Yeon Lee, Yeong-Nam Bae, Hyejin Lee, Yong‐Sung Kim, Bo-Seong Jeong, Byung‐Ha Oh
This paper computationally designs and experimentally validates a single-domain antibody that specifically recognizes a WT1 peptide-loaded class I MHC complex with high affinity and specificity.
bioRxiv · Jul 24, 2025 · PreprintBiochemistry