Julian M. Hahnfeld

Generative models for antimicrobial peptide design: auto-encoders and beyond

This study compares deep learning models for generating antimicrobial peptides, finding that auto-encoders, especially Wasserstein auto-encoders, produce more diverse sequences than other models.

Predicted Bacterial uRBSs Reveal Translational Coupling and Ribosome Mediated RBS Occlusion as Gene-Controlling Mechanisms

The paper identifies uORFs in bacterial mRNAs using bioinformatics and experimental validation, revealing translational coupling and ribosome-mediated RBS occlusion as regulatory mechanisms.

sORFdb - A database for sORFs, small proteins, and small protein families in bacteria

sORFdb is a database for small proteins and sORFs in bacteria, addressing gaps in detection and functional annotation through curated data and family classification.