Chien-Min Kao

The paper investigates how nicotine and varenicline distribute in brain cells by combining in vitro and in vivo imaging, finding that varenicline is trapped in 4{beta}2R-containing Golgi satellites, leading to slow release.

This study evaluates an image-derived input function for PET ligand kinetic modeling in mice, showing improved quantification compared to reference tissue methods for nicotinic receptor-binding tracers.