Author

Nathanial Holderman

University of Chicago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Neuroscience· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:imaging· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Chien-Min KaoiD· 2 shared Chin-Tu Chen· 2 shared Hannah J. Zhang· 2 shared Jogeshwar MukherjeeiD· 2 shared Matthew D. ZammitiD· 2 shared Mohammed P. I. BhuiyaniD· 2 shared Richard H. Freifelder· 2 shared Samuel J. Mitchell· 2 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Chien-Min KaoORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed by in vitro Cellular Studies and in vivo PET Imaging

Hannah J. Zhang, Matthew D. Zammit, Chien-Min Kao, Anitha P. Govind, Samuel J. Mitchell, Nathanial Holderman, Mohammed P. I. Bhuiyan, Richard H. Freifelder, Anna Kucharski, Xiaoxi Zhuang, Jogeshwar Mukherjee, Chin-Tu Chen, William N. Green

The paper investigates how nicotine and varenicline distribute in brain cells by combining in vitro and in vivo imaging, finding that varenicline is trapped in 4{beta}2R-containing Golgi satellites, leading to slow release.

Journal of Neuroscience · Aug 26, 2022Peer-reviewedNeuroscience

Evaluation of an image-derived input function for kinetic modeling of nicotinic acetylcholine receptor-binding PET ligands

Matthew D. Zammit, Chien-Min Kao, Hannah J. Zhang, Nathanial Holderman, Samuel J. Mitchell, Eve Tanios, Vincent Zhang, Mohammed P. I. Bhuiyan, Richard H. Freifelder, William N. Green, Jogeshwar Mukherjee, Chin-Tu Chen

This study evaluates an image-derived input function for PET ligand kinetic modeling in mice, showing improved quantification compared to reference tissue methods for nicotinic receptor-binding tracers.

bioRxiv · Aug 5, 2022 · PreprintNeuroscience