Author

Samuel J. Mitchell

University of Chicago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Assay:imaging· 3 Organism:mouse· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Chin-Tu Chen· 3 shared Hannah J. Zhang· 3 shared Chien-Min KaoiD· 2 shared Jogeshwar MukherjeeiD· 2 shared Matthew D. ZammitiD· 2 shared Mohammed P. I. BhuiyaniD· 2 shared Nathanial Holderman· 2 shared Richard H. Freifelder· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersNeuroscience

Chin-Tu Chen

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Author profile →

4 papers

Recent·Most cited

Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed by in vitro Cellular Studies and in vivo PET Imaging

Hannah J. Zhang, Matthew D. Zammit, Chien-Min Kao, Anitha P. Govind, Samuel J. Mitchell, Nathanial Holderman, Mohammed P. I. Bhuiyan, Richard H. Freifelder, Anna Kucharski, Xiaoxi Zhuang, Jogeshwar Mukherjee, Chin-Tu Chen, William N. Green

The paper investigates how nicotine and varenicline distribute in brain cells by combining in vitro and in vivo imaging, finding that varenicline is trapped in 4{beta}2R-containing Golgi satellites, leading to slow release.

Journal of Neuroscience · Aug 26, 2022Peer-reviewedNeuroscience

Evaluation of an image-derived input function for kinetic modeling of nicotinic acetylcholine receptor-binding PET ligands

Matthew D. Zammit, Chien-Min Kao, Hannah J. Zhang, Nathanial Holderman, Samuel J. Mitchell, Eve Tanios, Vincent Zhang, Mohammed P. I. Bhuiyan, Richard H. Freifelder, William N. Green, Jogeshwar Mukherjee, Chin-Tu Chen

This study evaluates an image-derived input function for PET ligand kinetic modeling in mice, showing improved quantification compared to reference tissue methods for nicotinic receptor-binding tracers.

bioRxiv · Aug 5, 2022 · PreprintNeuroscience

Assessment of Brain Glucose Metabolism Following Cardiac Arrest by FDG Positron Emission Tomography

Hannah J. Zhang, Samuel J. Mitchell, Yong‐Hu Fang, Hsiu‐Ming Tsai, Lin Hua Piao, Alaa Ousta, Lara Leoni, Chin-Tu Chen, Willard W. Sharp

This study uses [18F]FDG-PET to assess brain glucose metabolism 72 hours after cardiac arrest in mice, finding increased uptake in multiple brain regions.

Neurocritical Care · May 1, 2020Peer-reviewedNeuroscience

Multiple genetic loci affect place learning and memory performance in Drosophila melanogaster

Patricka A. Williams‐Simon, Christopher Posey, Samuel J. Mitchell, Enoch Ng’oma, James A. Mrkvicka, Troy D. Zars, Elizabeth G. King

The paper identifies 16 genetic loci affecting place learning and memory in Drosophila melanogaster using a multiparent mapping resource and transcriptomic analysis.

Genes Brain & Behavior · May 16, 2019Peer-reviewedGenetics