Immo Prinz

This study shows that γδ T cell-derived IL-17A worsens experimental EBA, and IL-1β drives IL-17A production in these cells.

This study maps the aging trajectories of human γδ T cells using single-cell transcriptomics, revealing non-linear aging with distinct childhood transitions and stability in adulthood.

SCALE identifies multi-scale functional domains in spatial transcriptomics data using neural graph learning and entropy-based search, achieving state-of-the-art performance on simulated and biological datasets.

The paper develops an in situ hybridization method to analyze T cell clonality in kidney biopsies and finds spatial clustering of clonally related T cells near antigen-presenting cells.

This study shows that the ISR/eIF2α pathway regulates cytokine mRNA translation in Trm cells, limiting their activity in homeostasis but enabling rapid response during inflammation or autoimmunity.

The paper compares TCR-pMHC prediction models and finds they lack generalization and robustness due to data dependency.