Mengping Long

SIMPlex generates matched spatial and single-nucleus transcriptomic profiles from the same tissue section to resolve cell states with spatial signatures in mouse and human cancer tissues.

COSTE embeds spatial relationships into a hierarchical metric space to reveal tissue architecture in spatial omics data, identifying spatially defined cell states and disease-associated patterns.

This study identifies molecular features of triple-negative apocrine carcinoma through proteogenomic analysis, revealing resistance mechanisms and suggesting alternative therapeutic strategies.

The paper compares Mass Spectrometry (MS) and Reverse Phase Protein Array (RPPA) in TNBC samples to assess their performance and identify complementary proteomic profiles.

This study identifies H4G, a novel histone variant overexpressed in breast cancer tissues, which localizes to nucleoli and enhances rDNA transcription by destabilizing nucleosomes.