Andrew M. Erickson

Spatial transcriptomics reveals interferon pathway enrichment in early relapsing serous carcinoma

This study uses spatial transcriptomics to identify interferon pathway enrichment in early relapsing high-grade serous carcinoma, linking it to poor prognosis and suggesting C3 as a biomarker.

Highly resolved tumor architecture via matched spatial and nucleus transcriptomics from a single tissue section

SIMPlex generates matched spatial and single-nucleus transcriptomic profiles from the same tissue section to resolve cell states with spatial signatures in mouse and human cancer tissues.

Spatial mapping of pediatric brain tumors across diagnoses and relapses

The paper creates a spatial transcriptomic atlas of pediatric brain tumors, identifying spatial archetypes and relapse-associated clones across multiple diagnoses.

Immunosuppression in the prostate tumor microenvironment is tied to androgen deprivation therapy-resistant club-like cells

The paper identifies club-like cells in the prostate tumor microenvironment that contribute to androgen deprivation therapy resistance through immune suppression.

Clonal phylogenies inferred from bulk, single cell, and spatial transcriptomic analysis of cancer

The paper evaluates the accuracy of transcript-based inferred tumor phylogenies compared to DNA-based phylogenies in prostate cancer using single-cell, spatial transcriptomic, and bulk data.

The spatial landscape of clonal somatic mutations in benign and malignant tissue

The paper uses spatial transcriptomics to analyze copy number variations in benign and malignant tissues, revealing clonal patterns and suggesting early cancer evolution mechanisms.