Huiling Zhao

This study uses Mendelian randomization to investigate the causal effects of ABO protein levels on pregnancy outcomes, finding potential causal links to venous complications and haemorrhoids.

This paper uses Mendelian randomization and electronic health records to show SGLT2 inhibitors reduce prostate cancer risk, with additional evidence from differential expression analysis.

This study evaluates polygenic risk score methods across diverse biobanks and ancestries, finding that European reference panels often yield better performance, while PRS-CS outperforms P+T for high-heritability traits.

This paper shows that meta-analysis fine-mapping is often miscalibrated due to cohort heterogeneity and introduces a QC method to identify suspicious loci.

This paper uses proteome-wide Mendelian randomization across multiple ancestries to identify causal protein-disease associations and drug targets in over 1.26 million individuals.

Meta-analysis of harmonized GWAS from up to 18 biobanks (six ancestry groups) across 14 endpoints replicated 320 known loci and identified 188 apparently novel loci.

This study uses multi-ancestry Mendelian randomization to identify six protein targets for COVID-19 severity, showing ancestry-specific effects.